GABA and glutamate are not colocalized in mossy fiber terminals of developing rodent hippocampus
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چکیده
منابع مشابه
Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus.
Hippocampal mossy fibers of young rodents have been reported to corelease inhibitory neurotransmitter GABA in addition to excitatory transmitter glutamate. In this study, we aimed at re-evaluating this corelease hypothesis of both inhibitory and excitatory transmitters in the hippocampus. Electrophysiological examination revealed that, in juvenile mice and rats of the two to 3 weeks old, stimul...
متن کاملIn the developing rat hippocampus, endogenous activation of presynaptic kainate receptors reduces GABA release from mossy fiber terminals.
Presynaptic kainate receptors regulate synaptic transmission in several brain areas but are not known to have this action at immature mossy fiber (MF) terminals, which during the first week of postnatal life release GABA, which exerts into targeted cells a depolarizing and excitatory action. Here, we report that, during the first week of postnatal life, endogenous activation of GluK1 receptors ...
متن کاملIs GABA co-released with glutamate from hippocampal mossy fiber terminals?
Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information of the format and purpose of the Journal Club, please see Review of Cabezas et al. The coexistence and co-release of differ...
متن کاملControl of GABA Release at Mossy Fiber-CA3 Connections in the Developing Hippocampus
In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. While in adulthood MF, the axons of dentate gyrus granule cells release onto CA3 principal cells and interneurons glutamate, early in postnatal life they release GABA, which exerts into targete...
متن کاملGABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus.
Profound activity-dependent synaptic facilitation at hippocampal mossy fiber synapses is a unique and functionally important property. Although presynaptic ionotropic receptors, such as kainate receptors, contribute partially to the facilitation in the hippocampus, the precise mechanisms of presynaptic regulation by endogenous neurotransmitters remain unclear. In this study, we report that axon...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2012
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2012.07.042